Perioperative medicine & outcomes
Impact of intravenous steroids on subjective recovery quality after surgery: A meta-analysis of randomized clinical trials
Authors' conclusion
Intravenous administration of steroids significantly improved QoR after surgery.
Study context
- Population
- Adults undergoing surgery under GA
- Participants
- 951 adults · 11 randomized controlled trials (RCTs)
- Comparison
- Single-dose IV steroids vs placebo or no treatment
- Outcome
- Global QoR scores (QoR-15 and QoR-40)
- Follow-up
- POD 1 and 2-3
Pooled result
As reported in the abstract
Global QoR scores
Steroid vs ControlSMD (95 % CI)P value
POD 1
0.52(0.22–0.82)
P = 0.0007POD 2-3
0.50(0.19–0.81)
P = 0.001Further pooled results
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| Analgesic rescue | 0.77 (0.67–0.88) | P = 0.0003 | |
| PONV incidence | 0.73 (0.56–0.95) | P = 0.02 | |
| 0.512Relative risk (log scale) |
| Outcome | SMD (95 % CI) | P value | |
|---|---|---|---|
| Postoperative pain scores | −0.41 (−0.68 to −0.14) | P = 0.003 | |
| −1−0.500.5Difference (linear scale) |
Quality of recovery (QoR) dimensions · postoperative days (POD) 1
- Significant improvements in all QoR dimensions, effect sizes small to moderate
Original publication
Impact of intravenous steroids on subjective recovery quality after surgery: A meta-analysis of randomized clinical trials. J Clin Anesth. Published 17 September 2024. doi:10.
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