Perioperative medicine & outcomes
The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials
Authors' conclusion
This meta-analysis demonstrated that ketamine/esketamine use in the perioperative period is associated with improved early subjective QoR, pain severity, and psychological symptoms without an increase in the likelihood of adverse events.
Study context
- Population
- Surgical patients; 15 of 18 randomised controlled trials (RCTs) conducted in China
- Participants
- 1,554 patients · 18 RCTs
- Comparison
- Perioperative ketamine/esketamine vs control
- Outcome
- Subjective QoR (QoR-9, QoR-15, QoR-40)
- Follow-up
- POD 1-3
Methodological detailssubgroup analyses
- Subgroup analyses
Pooled result
As reported in the abstract
Subjective QoR scores (QoR-9, QoR-15, QoR-40)
SMD
0.63
P < 0.0001
Postoperative day (POD) 1
SMD
0.56
P = 0.04
POD 2
Further pooled results
| Outcome | SMD | P value |
|---|---|---|
| Postoperative anxiety scores | −0.48 | P = 0.003 |
| Postoperative depression scores | −0.72 | P = 0.001 |
Quality of recovery (QoR) on POD 1 by regimen (subgroup)
- Esketamine SMD
- 1.14
- Ketamine SMD
- 0.01
- Significant subgroup difference
QoR on POD 1 by country (subgroup)
- China SMD
- 0.82
- Other countries SMD
- −0.21
- Significant subgroup difference
QoR domains
- Emotional domain improved from PODs 1 to 3; other domains improved only on POD 1
Pain severity
- Reduced on PODs 1 and 2
LOS
- No difference
Safety
Adverse events (nausea, vomiting, dizziness, drowsiness)
- No difference in risk
Original publication
The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials. Br J Anaesth. Published 12 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →