Cardiac arrest & resuscitation
Impact of mild hypercapnia on renal function after out-of-hospital cardiac arrest
Authors' conclusion
AKI occurred in approximately two-thirds and RRT in approximately one in ten TAME patients without differences according to treatment allocation. CS significantly increased the prevalence of AKI but this effect was not modified by carbon dioxide allocation.
Study context
- Population
- Patients after out-of-hospital cardiac arrest (OHCA), with or without cardiogenic shockof 1700 TAME patients
- Participants
- 1,668 patients
- Comparison
- Targeted mild hypercapnia vs targeted normocapnia
- Primary endpoint
- AKI by modified KDIGO criteria
Methodological detailspre-planned exploratory, multi-national
- Pre-planned exploratory
- Multi-national
Primary result
As reported in the abstract
AKI
- Acute kidney injury (AKI) overall
- 1203 patients (72.1%)
Secondary outcomes
Stage 3 AKI
RRT
Favourable neurological outcome (GOSE 5-8), by AKI · six-months
- No AKI
- 237 of 429 (55.2%)
- AKI
- 445 of 1111 (40.1%)
- No AKI vs AKI
- P < 0.0001
AKI in patients with cardiogenic shock (CS)
- AKI more frequent in CS
- 936 patients (77.8%); P < 0.001
Secondary outcomes in CS and AKI patients
- No significant differences in any secondary outcome
Original publication
Impact of mild hypercapnia on renal function after out-of-hospital cardiac arrest. Resuscitation. Published 30 December 2024. doi:10.
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