Neuroanesthesia & neurocritical care
Impact of rapid-eye-movement sleep behavior disorder on propofol anesthesia depth monitoring in parkinson’s disease
Authors' conclusion
Collectively, PD-RBD patients exhibit abnormal EEG under propofol anesthesia but maintain reliable depth-of-anesthesia indices
Study context
- Population
- Parkinson's disease (PD) patients undergoing subthalamic nucleus deep brain stimulation
- Participants
- 43 patients
- Exposure
- PD patients with RBD vs without RBD under propofol anesthesia
- non-RBDn = 23reference
- RBDn = 20
- Outcome
- Coherence between anesthesia depth indices and neurophysiological states (EEG power spectral density, derived parameters) across awake, propofol anesthesia and propofol light anesthesia states
Methodological detailsSedLine-monitored prefrontal EEG
- SedLine-monitored prefrontal EEG
Main finding
As reported in the abstract
Anesthesia depth indices and EEG
- Comparable patient state index, spectral edge frequency and suppression ratio under anesthesia
- RBD vs non-RBD: P = 0.034
- RBD vs non-RBD: P = 0.027
- RBD vs non-RBD: P = 0.011
Observational data: associations, not effects.
Further findings
Postoperative delirium risk factors (logistic regression)
- Delirium risk associated with RBD status, Mini-Mental State Examination scores and propofol-induced theta power; theta power protective
Safety
- Postoperative delirium — RBD
- 65.00%
Postoperative delirium
- Higher incidence in RBD
Original publication
Impact of rapid-eye-movement sleep behavior disorder on propofol anesthesia depth monitoring in parkinson’s disease. J Clin Monit Comput. Published 9 December 2025. doi:10.
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