Neuroanesthesia & neurocritical care

Deep brain stimulation under general anaesthesia for Parkinson's disease: A retrospective evaluation of perioperative events and anaesthetic management after switching away from conscious sedation

Acta Anaesthesiol ScandPublished Retrospective descriptive comparative study

Authors' conclusion

Deep brain stimulation under GA was associated with fewer perioperative incidents, shorter surgeries and shorter hospital stays.

Study context

Population
Patients with refractory Parkinson's disease undergoing deep brain stimulation; one-third women, median age 62 years (range, 33–75)procedures analysed
Participants
Seventy-eight patients
Exposure
Deep brain stimulation under general anaesthesia (GA) vs conscious sedation
  • Conscious sedation (CS)n = 36reference
  • GAn = 42
Outcome
Perioperative incidents (haemodynamic, neurologic and surgery-related)

Main finding

As reported in the abstract

At least one perioperative incident

P < 0.001

Observational data: associations, not effects.

Further findings

Duration of surgery · CS split into two sessions

P < 0.001

Hospital LOS

P < 0.0001

OutcomeCSGAP value
Disorientation/agitation12 events— not stated in the abstractP < 0.01

— not stated in the abstract

Disorientation/agitation — Total disorientation/agitation
14 (17.9%)

Movement disorder scores (38 of 78 patients [49%] evaluated)

No difference between groups before surgery
P = 0.41
No difference between groups after surgery
P = 0.52
Significantly improved scores after surgery

Original publication

Deep brain stimulation under general anaesthesia for Parkinson's disease: A retrospective evaluation of perioperative events and anaesthetic management after switching away from conscious sedation. Acta Anaesthesiol Scand. Published 24 March 2025. doi:10.1111/aas.70017

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