Neuroanaesthesia & neurocritical care
General anesthesia versus non-general anesthesia in young adults undergoing thrombectomy
Pooled resultResult — go to the resultRD 0.12 95% CI 0.02–0.25Authors' conclusion
In this emulated trial involving young stroke patients undergoing EVT, non-GA was associated with a higher likelihood of functional independence compared to GA with similar reperfusion success and sICH.
Study context
- Population
- Young adults aged 18–50 years with anterior circulation large vessel occlusion (LVO) undergoing endovascular thrombectomy (EVT)
- Participants
- 284 adults
- Comparison
- Non-GA vs GA during EVT
- GAn = 94reference
- non-GAn = 190
- Outcome
- Functional independence (mRS 0-2)
- Follow-up
- 90 days
Methodological detailstarget trial emulation, inverse probability of treatment weighting, G-computation
- Target trial emulation
- Inverse probability of treatment weighting
- G-computation
Pooled result
As reported in the abstract
RD
0.12
95% CI 0.02–0.25
non-GA vs GA
RD 0.12 (95% CI 0.02–0.25)
Further pooled results
Reperfusion success
- Did not differ significantly between groups
Mortality and symptomatic intracranial hemorrhage (sICH)
- Did not differ significantly between groups
Safety
| Outcome | RD (95% CI) | |
|---|---|---|
| PneumoniaIncreased incidence with GA | −0.21 (−0.35 to −0.11) | |
| −0.4−0.200.2Difference (linear scale) |
Original publication
General anesthesia versus non-general anesthesia in young adults undergoing thrombectomy. Anaesth Crit Care Pain Med. Published 5 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →