Pediatric anesthesia & critical care
Impact of substance use disorders on critical care management and health outcomes in septic adolescents
Authors' conclusion
Our retrospective analysis suggests history of SUD in critically ill septic adolescent patients is associated with increased utilization of critical care resources and organ dysfunction.
Study context
- Population
- Critically ill adolescents aged 12–21 years hospitalized with sepsis, predominantly US healthcare organizations
- Participants
- 5,436 adolescents
- Exposure
- SUD history vs no-SUD history
- SUD historyn = 730
- no-SUD historyn = 4,706reference
- Outcome
- Organ dysfunction, critical care therapies, and all-cause 1-year mortality
Methodological detailsTriNetX electronic health record (EHR) database
- TriNetX EHR database
Main finding
As reported in the abstract
Each group vs no-SUD historyEstimate (95% CI)P value
SUD history
aOR (organ dysfunction) 1.84(1.56–2.16)
P < 0.001SUD history
aOR (vasoactive/inotropic drug usage) 1.29(1.10–1.52)
P = 0.002SUD history
aOR (mechanical ventilation) 2.19(1.85–2.59)
P < 0.001SUD history
aOR (all-cause 1-year mortality) 1.03(0.76–1.41)
P = 0.83Observational data: associations, not effects.
Original publication
Impact of substance use disorders on critical care management and health outcomes in septic adolescents. Ann Intensive Care. Published 10 May 2025. doi:10.
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