Pediatric anesthesia & critical care
Association Between High‐Risk Preexisting Substance Use and Increased Postoperative Opioid Dose Use Among Adolescents Undergoing Ambulatory Orthopedic Surgery
Main finding · Postoperative opioid dosesResult — go to the resultIncidence rate ratio 1.96 95% CI 1.12–3.43Authors' conclusion
High-risk preoperative substance use was associated with increased postoperative opioid use in opioid-naïve adolescents following elective ambulatory orthopedic surgery.
Study context
- Population
- Opioid-naive adolescents undergoing ambulatory orthopedic surgery
- Participants
- 121 adolescents
- Exposure
- High-risk preoperative substance use vs no substance use
- High-risk substance usen = 13
- Outcome
- Postoperative opioid dose use
Methodological detailsobjective electronic medication adherence device, smartphone pain diary
- Objective electronic medication adherence device
- Smartphone pain diary
Main finding
Postoperative opioid doses
Incidence rate ratio
1.96
95% CI 1.12–3.43
P = 0.018
By group
High-risk substance use vs No substance use
IRR 1.96 (95% CI 1.12–3.43); P = 0.018
As reported in the abstract
Observational data: associations, not effects.
Further findings
Opioid use vs pain intensity (longitudinal) · 14 days
- High-risk substance use: more opioids overall and less likely to vary opioid use in response to lower pain intensity vs no substance use
Original publication
Association Between High‐Risk Preexisting Substance Use and Increased Postoperative Opioid Dose Use Among Adolescents Undergoing Ambulatory Orthopedic Surgery. Paediatr Anaesth. Published 22 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →