Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults

Casaer, MP; Stragier, H; Hermans, G; Hendrickx, A; Wouters, PJ; Dubois, J; Guiza, F; Van den Berghe, G; Gunst, J

doi:10.1007/s00134-024-07546-w

Organ support & nutrition

Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults

Intensive Care MedPublished 17 Jul 2024Prospective follow-up study of the EPaNIC randomised controlled trial

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Authors' conclusion

Late-PN did not alter 2-year survival and physical functioning in adult critically ill patients, independent of anticipated nutritional risk.

Study context

Population: Critically ill adults3,292 survivors for SF-36
Participants: 4,640 adults

Comparison: Late-PN vs Early-PN
Primary endpoint: 2-year mortality and physical functioning (SF-36)
Follow-up: 2 years

Methodological detailsmulticentre, imputed models for missing data, nutritional risk subgroup analysis

Multicentre
Imputed models for missing data
Nutritional risk subgroup analysis

Original publication

Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults. Intensive Care Med. Published 17 July 2024. doi:10.1007/s00134-024-07546-w

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