Anaesthetic drugs & techniques
Impact of propofol‐based vs. volatile‐based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta‐analysis of randomised trials
Pooled result · Overall survivalResult — go to the resultHazard ratio 1.05 95% CI 0.94–1.17Authors' conclusion
Propofol-based and volatile-based anaesthesia yield similar long-term oncological outcomes, with no significant differences in survival or recurrence and minimal heterogeneity, supported by high-certainty evidence.
Study context
- Population
- Adults undergoing curative cancer surgery11 RCTs
- Participants
- 3,904 vs 3,907
- Comparison
- Propofol-based vs volatile-based anaesthesia
- Propofol-basedn = 3,904
- Volatile-basedn = 3,907reference
- Outcome
- Overall survival and recurrence
Methodological detailsrandom-effects meta-analysis, exploratory trial sequential analysis
- Random-effects meta-analysis
- Exploratory trial sequential analysis
Pooled result
Overall survival
Hazard ratio
1.05
95% CI 0.94–1.17
P = 0.42
Propofol-based vs Volatile-based
HR 1.05 (95% CI 0.94–1.17); P = 0.42
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrence-free survivalRandom-effects meta-analysis · minimal heterogeneity | 1.06 (0.95–1.19) | P = 0.31 | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of propofol‐based vs. volatile‐based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta‐analysis of randomised trials. Anaesthesia. Published 17 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →