The Impact of Utilizing Combined Factor Concentrates for Hemostasis Management in Pediatric Pulmonary Artery Reconstruction: A Propensity Score‐Matched Cohort Study
Authors' conclusion
A hemostasis management pathway utilizing combined factor concentrates was associated with significantly reduced post-bypass transfusion requirements in pediatric pulmonary artery reconstruction.
Study context
- Population
- Pediatric patients undergoing pulmonary artery reconstruction with CPB87 per cohort after matching
- Participants
- 87 vs 87
- Exposure
- Post-pathway vs pre-pathway
- Post-pathwayn = 87
- Pre-pathwayn = 87reference
- Outcome
- Total blood product transfused after CPB
Methodological detailspropensity score-matched, before-after pathway implementation
- Propensity score-matched
- Before-after pathway implementation
Main finding
Total blood products transfused
Mean difference
17.6 mL/kg
95% CI 9.82–25.9
P < 0.0001
By group
Post-pathway vs Pre-pathway
mean difference 17.6 mL/kg (95% CI 9.82–25.9); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
24-h chest tube output, time to extubation, LOS, 30-day mortality, AKI
- No significant differences in secondary outcomes
Safety
| Outcome | Post-pathway | Pre-pathway | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Thromboembolism (primary safety outcome) · 7 days | 11.5% | 8.0% | 1.48 (0.51–4.32) | P = 0.468 | |
| Thromboembolism (primary safety outcome) · 30 days | 18.4% | 9.2% | 2.23 (0.84–5.87) | P = 0.106 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
The Impact of Utilizing Combined Factor Concentrates for Hemostasis Management in Pediatric Pulmonary Artery Reconstruction: A Propensity Score‐Matched Cohort Study. Paediatr Anaesth. Published 24 April 2026. doi:10.
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