Perioperative medicine & outcomes

Impaired Cognitive Domains in Surgical Patients: A Systematic Review and Meta-Analysis

Anesth AnalgPublished Systematic review and meta-analysis

Authors' conclusion

The prevalence of preoperatively impaired cognitive domains was the highest in executive function, followed by visuospatial function and attention/working memory/processing speed.

Study context

Population
Surgical patients ≥18 years of age with preoperative cognitive assessment by neuropsychological battery (excluding neurological surgery)
Participants
5,725 patients · 21 studies
Outcome
Perioperative prevalence of impaired cognitive domains
Methodological details11 non-cardiac surgery studies, 10 cardiac surgery studies; 5 databases searched to March 19, 2024
  • 11 non-cardiac surgery studies, 10 cardiac surgery studies; 5 databases searched to March 19, 2024

Pooled result

As reported in the abstract

Preoperative pooled prevalence of impairment by cognitive domain · Preoperative
Executive function
18%; 95% CI, 13%-24%
Visuospatial function
16%; 95% CI, 6%-26%
Attention/working memory/processing speed
14%; 95% CI, 9%-18%
Perceptual-motor control
13%; 95% CI, 9%-36%
Language
13%; 95% CI, 8%-17%
Learning/memory
12%; 95% CI, 8%-16%

Further pooled results

Postoperative pooled prevalence of impairment by cognitive domain · 1 week

Attention/working memory/processing speed
35% (95% CI, 4%-66%)
Executive function
34% (95% CI, 16%-51%)
Learning/memory
28% (95% CI, 16%-40%)

Postoperative pooled prevalence of impairment by cognitive domain · within 3 months

Attention/working memory/processing speed
16% (95% CI, 3%-35%)
Executive function
15% (95% CI, 6%-24%)
Learning/memory
12% (95% CI, −2% to 25%)

Original publication

Impaired Cognitive Domains in Surgical Patients: A Systematic Review and Meta-Analysis. Anesth Analg. Published 13 February 2026. doi:10.1213/ane.0000000000007948

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