Perioperative medicine & outcomes
Perioperative Best Practices and Delirium in Patients With Cognitive Impairment
Authors' conclusion
This cohort study of surgical patients with cognitive impairment found that current perioperative strategies derived from established recommendations, while foundational, were insufficient to prevent postoperative delirium.
Study context
- Population
- Adults scheduled for surgery with preoperative cognitive impairment, ≥1 postoperative night in hospital, academic medical center in New York, 2023–2024
- Participants
- 1,255 adults
- Exposure
- Adherence to 12 perioperative best practices and postoperative delirium
- Outcome
- Postoperative delirium (4 A's Test)
Methodological detailssecondary, exploratory analysis of a randomized clinical trial, single-centre
- Secondary, exploratory analysis of a randomized clinical trial
- Single-centre
Main finding
As reported in the abstract
Postoperative delirium
Adjusted odds ratio (95% CI)P value
Glucose <200 mg/dLseparate model
0.41(0.24–0.69)
P = 0.001Temperature probeseparate model
0.65(0.45–0.96)
P = 0.03Temperature >36 °Cseparate model
0.64(0.43–0.94)
P = 0.03Postoperative glucose monitoringconcurrent model
1.54(1.11–2.13)
P = 0.009- Delirium incidence
- 426 (33.9%; 95% CI, 31.4%-36.6%)
Observational data: associations, not effects.
Original publication
Perioperative Best Practices and Delirium in Patients With Cognitive Impairment. JAMA Netw Open. Published 2 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →