Implementation of Nephroprotective Measures to Prevent Acute Kidney Injury in Septic Patients: A Retrospective Cohort Study
Authors' conclusion
Implementation of the KDIGO bundle is poor in patients with sepsis but may be associated with improved outcomes.
Study context
- Population
- Septic patients with and without acute kidney injury (AKI) in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
- Participants
- 34,679 patients
- Outcome
- Adherence to the KDIGO bundle (avoidance of nephrotoxic agents, functional hemodynamic monitoring, optimization of perfusion pressure and volume status, close monitoring of renal function, avoidance of hyperglycemia, avoidance of radiocontrast agents)
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
KDIGO bundle adherence
- Complete bundle received
- 1.6%
- 5 bundle components received
- 10%
- 4 bundle components received
- 42.3%
- 3 bundle components received
- 35.4%
- 2 bundle components received
- 9.8%
- Nephrotoxic agents avoided
- 56.4%
- Hemodynamic optimization reached
- 86.5%
Observational data: associations, not effects.
Secondary outcomes
Secondary end points (AKI development and progression, renal replacement therapy (RRT), mortality, composite of AKI progression and mortality within 7 days)
- Improved in patients with bundle adherence
AKI and patient outcomes incl. 30-day mortality, by bundle component
- Avoidance of nephrotoxic drugs and optimization of hemodynamics significantly associated with lower AKI rates and improved outcomes, incl. 30-day mortality
Original publication
Implementation of Nephroprotective Measures to Prevent Acute Kidney Injury in Septic Patients: A Retrospective Cohort Study. Anesth Analg. Published 9 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →