Perioperative medicine & outcomes
Improving Surgical Care and Outcomes in Older Cancer Patients Through Implementation of a Presurgical Toolkit (OPTI-Surg)—Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD)
Authors' conclusion
Frailty assessment was successfully performed, but the OPTI-Surg intervention did not improve postoperative function nor reduce postoperative complications compared with UC.
Study context
- Population
- Patients 70 years old or above undergoing curative intent thoracic, gastrointestinal or urologic oncological surgery in NCORP practices
- Participants
- 325 patients · 29 practices
- Comparison
- OPTI-Surg vs usual care
- Usual care (UC)n = 64reference
- OPTI-Surgn = 135
- Primary endpoint
- Postoperative function (kcal/wk)
- Follow-up
- 8 weeks postoperative
Methodological detailsphase III, cluster randomized, 1:1:1 randomization, multicentre (29 practices)
- Phase III
- Cluster randomized
- 1:1:1 randomization
- Multicentre (29 practices)
Primary result
As reported in the abstract
Total caloric expenditure
UC
2.2
OPTI-Surg
2.0
P = 0.53
Secondary outcomes
Postoperative complications (key secondary) · within 90 days · not significantly different
P = 0.5
- Postoperative complications (key secondary): 279 evaluable (78 UC, 201 OPTI-Surg)
Original publication
Improving Surgical Care and Outcomes in Older Cancer Patients Through Implementation of a Presurgical Toolkit (OPTI-Surg)—Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD). Ann Surg. Published 29 July 2024. doi:10.
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