Perioperative medicine & outcomes
Remimazolam tosylate or propofol and delirium in frail elderly patients after hip surgery: A randomised controlled clinical trial
Authors' conclusion
In frail elderly patients, remimazolam tosylate was associated with a lower incidence of postoperative delirium compared with propofol.
Study context
- Population
- Frail elderly patients (Reported Edmonton Frail Scale Score ≥ 6) undergoing hip surgery under GA, tertiary teaching hospital in China, March to December 2023enrolled
- Participants
- 136 patients
- Comparison
- Remimazolam tosylate vs propofol TIVA for induction and maintenance
- Remimazolamn = 68
- Propofoln = 68reference
- Primary endpoint
- Incidence of postoperative delirium (3D-CAM, assessed twice daily)
- Follow-up
- Within three postoperative days
Methodological detailssingle-centre, single-blind
- Single-centre
- Single-blind
Primary result
As reported in the abstract
Remimazolam vs PropofolRisk difference (95% CI)P value
NNT 7.6
−13.2%(−23.5% to −2.9%)
P = 0.0143Remimazolam vs PropofolRelative risk (95% CI)P value
Remimazolam
0.25(0.074–0.847)
P = 0.0143Secondary outcomes
s
| Outcome | Remimazolam | Propofol | Median difference (s) (95% CI) | P value | |
|---|---|---|---|---|---|
| Burst suppression time | 2.2 (range 0–17.6) | 21.9 (range 2.3–115.3) | 11.98 (2.44–27.90) | P < 0.001 | |
| −2002040Difference, s (linear scale) |
‰
| Outcome | Remimazolam | Propofol | Median difference (‰) (95% CI) | P value | |
|---|---|---|---|---|---|
| Burst suppression proportion of total surgery time | 0.3 (range 0–2.1) | 2.8 (range 0.2–14.7) | 1.30 (0.27–3.34) | P < 0.001 | |
| −2024Difference, ‰ (linear scale) |
Safety
| Outcome | Remimazolam | Propofol | RD (95% CI) | P value | |
|---|---|---|---|---|---|
| Hypotension after inductionNNT 4.3 | 23.5% | 47.1% | −23.5% (−39.1% to −8.0%) | P = 0.004 | |
| Vasopressor requirementNNT 6.2 | 80.9% | 97.1% | −16.2% (−26.3 to −6.0) | P = 0.003 | |
| −40−20020Difference (linear scale) |
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Hypotension after induction | 0.5 (0.304–0.822) | P = 0.004 | |
| Vasopressor requirement | 0.8 (0.737–0.942) | P = 0.003 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Remimazolam tosylate or propofol and delirium in frail elderly patients after hip surgery: A randomised controlled clinical trial. Eur J Anaesthesiol. Published 27 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →