Sevoflurane or remimazolam anaesthesia and emergence agitation after nasal surgery in adults: A randomised clinical trial
Primary result · Emergence agitation (Richmond Agitation-Sedation Scale)Result — go to the resultRisk difference 12.2 95% CI 3.0–21.4Authors' conclusion
The occurrence of emergence agitation in adult patients after nasal surgery under general anaesthesia can be significantly reduced using remimazolam-based TIVA.
Study context
- Population
- Adults undergoing nasal surgery under GA, university-affiliated tertiary hospital
- Participants
- 98 adults
- Comparison
- Remimazolam-based total intravenous anaesthesia (TIVA) vs sevoflurane-based volatile induction and maintenance of anaesthesia (VIMA)
- Remimazolamn = 49
- Sevofluranen = 49reference
- Primary endpoint
- Occurrence of emergence agitation (Richmond Agitation-Sedation Scale and Riker Sedation-Agitation Scale)
Methodological detailsprospective, assessor-blinded, single-centre
- Prospective
- Assessor-blinded
- Single-centre
Primary result
As reported in the abstract
Emergence agitation (Richmond Agitation-Sedation Scale)
Risk difference
12.2
95% CI 3.0–21.4
P = 0.008
Events by treatment group
Sevoflurane vs Remimazolam
risk difference 12.2 (95% CI 3.0–21.4); P = 0.008
Secondary outcomes
Interval between discontinuation of anaesthesia and extubation · lower in the Remimazolam group
P < 0.001
Safety
| Outcome | Sevoflurane | Remimazolam | Risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Coughing (immediate complication after extubation) | 53.1% | 12.2% | 40.8 (24.0–57.5) | P < 0.001 | |
| −50050100Difference (linear scale) |
Original publication
Sevoflurane or remimazolam anaesthesia and emergence agitation after nasal surgery in adults: A randomised clinical trial. Eur J Anaesthesiol. Published 5 September 2025. doi:10.
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