Cardiothoracic & vascular anaesthesia
Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial
Primary result · Postoperative deliriumResult — go to the resultRelative risk 0.80 95% CI 0.55–1.16Authors' conclusion
Among patients undergoing on-pump cardiac valve surgery, anesthesia maintenance with a volatile agent did not result in significantly fewer occurrences of postoperative delirium than propofol-based TIVA.
Study context
- Population
- Adults scheduled for on-pump cardiac valve surgery or combined valve with coronary artery bypass grafting (CABG) surgery, university academic hospital in China, February 2019 to January 2021676 assessed for primary outcome
- Participants
- 684 adults
- Comparison
- Volatile anaesthesia vs propofol-based total intravenous anesthesia (TIVA) for anaesthesia maintenance
- Volatile anesthesian = 337
- Propofol-based TIVAn = 339reference
- Primary endpoint
- Incidence of delirium (CAM-ICU)
- Follow-up
- First 7 days after surgery
Methodological detailssingle-centre
- Single-centre
Primary result
Postoperative delirium
Relative risk
0.80
95% CI 0.55–1.16
P = 0.231
Events by treatment group
Volatile anesthesia vs Propofol-based TIVA
RR 0.80 (95% CI 0.55–1.16); P = 0.231
As reported in the abstract
Secondary outcomes
Duration and subtypes of delirium, 30-day mortality, pain score, major morbidity, duration of mechanical ventilation, intensive care unit (ICU) and hospital LOS
- No significant differences between the groups in any secondary outcome
Original publication
Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial. Anesth Analg. Published 27 October 2022. doi:10.
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