Cardiothoracic & vascular anesthesia
Comparison of Propofol-Based Total Intravenous Anesthesia versus Volatile Anesthesia with Sevoflurane for Postoperative Delirium in Adult Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Single-Blinded Study
An erratum to this article was published (J Cardiothorac Vasc Anesth, Aug 2026 ↗)
Primary result · DeliriumResult — go to the resultOdds ratio 1.72 95% CI 1.13–2.62Authors' conclusion
Propofol-based TIVA was associated with a lower incidence of delirium and POCD compared to sevoflurane in this cohort of patients undergoing CABG under CPB.
Study context
- Population
- Adults (>18 years) undergoing elective CABG with cardiopulmonary bypass (CPB)
- Participants
- 72 adults
- Comparison
- Propofol-based total intravenous anesthesia (TIVA) vs volatile anaesthesia with sevoflurane
- Propofoln = 36
- Sevofluranen = 36reference
Methodological detailsprospective, single-blinded, single-centre
- Prospective
- Single-blinded
- Single-centre
Primary result
Delirium
Odds ratio
1.72
95% CI 1.13–2.62
P = 0.027
Events by treatment group
As reported in the abstract
- Delirium overall
- 15 (21.7%)
Further findings
| Outcome | Propofol | Sevoflurane | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Early POCD · 1 week | 32.3% | 57.1% | 1.63 (1.01–2.62) | P = 0.038 | |
| 0.20.5125Odds ratio (log scale) |
Delirium, patients aged >65 years (subgroup)
P = 0.03
- Early postoperative cognitive dysfunction (POCD) — Early POCD overall
- 31 (44.9%)
Baseline and intraoperative variables (atheroma grades, near-infrared spectroscopy (NIRS), hemoglobin, glycemic control, oxygenation)
- Comparable in the 2 groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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