Cardiothoracic & vascular anaesthesia
Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial
Authors' conclusion
Remimazolam may offer improved hemodynamic stability during anesthetic induction in patients undergoing CABG, suggesting its potential advantage over propofol for patients with significant coronary artery disease in terms of hemodynamic stability.
Study context
- Population
- Adults undergoing isolated coronary artery bypass grafting (CABG), tertiary teaching hospital
- Participants
- 50 vs 50
- Comparison
- Remimazolam vs propofol for anesthetic induction
- Remimazolamn = 50
- Propofoln = 50reference
- Primary endpoint
- AUC below baseline mean arterial pressure (MAP)
- Follow-up
- First 10 min after anesthetic induction
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Mean difference
50.8 mmHg·min
95% CI 10.4–91.2
P = 0.014
By group
Remimazolam vs Propofol
mean difference 50.8 mmHg·min (95% CI 10.4–91.2); P = 0.014
Secondary outcomes
AUC for MAP <65 mmHg
P = 0.007
Vasopressor use
P = 0.001
Original publication
Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial. J Clin Anesth. Published 9 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →