Perioperative medicine & outcomes
Incidence of 12‐month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow‐up of the RAGA trial
An erratum to this article was published (Anaesthesia, Dec 2025 ↗)
Primary resultResult — go to the resultUnadjusted odds ratio 1.2 95% CI 0.7–2.1Authors' conclusion
The incidence of 12-month postoperative cognitive decline was not significantly different in patients having general or regional anaesthesia for hip fracture surgery.
Study context
- Population
- Patients aged ≥ 65 y with hip fractures requiring surgery, nine university hospitals in south-eastern China293 in primary analysis
- Participants
- 950 patients
- Comparison
- GA vs RA with no sedation
- Generaln = 474reference
- Regionaln = 476
- Primary endpoint
- Incidence of postoperative cognitive decline
- Follow-up
- 12 months post-randomisation
Methodological detailsmulticentre, 12-month follow-up substudy, Recruited October 2014 to September 2018; last interview November 2019
- Multicentre
- 12-month follow-up substudy
- Recruited October 2014 to September 2018; last interview November 2019
Primary result
As reported in the abstract
12 months
Unadjusted odds ratio
1.2
95% CI 0.7–2.1
P = 0.43
By group
General vs Regional
unadjusted OR 1.2 (95% CI 0.7–2.1); P = 0.43
Secondary outcomes
| Outcome | General | Regional | Unadjusted OR (95% CI) | |
|---|---|---|---|---|
| Major cognitive decline | 8.6% | 8.5% | 1.0 (0.4–2.4) | |
| 0.512Unadjusted odds ratio (log scale) |
Original publication
Incidence of 12‐month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow‐up of the RAGA trial. Anaesthesia. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →