Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study

Xu, J; Zhong, L; Shao, H; Wang, Q; Dai, M; Shen, P; Xiong, Y; Zhang, W; Deng, X; Wang, M; Zhu, Y; Reng, X; Jiang, Y; Chen, M; Zhu, C; Fang, X; He, G; Han, Y; Huang, X; He, X; Xu, Y; Cai, H; Huang, L

doi:10.1186/s13054-023-04530-6

Sepsis & infection

Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study

Crit CarePublished 23 Jun 2023Retrospective cohort study

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Authors' conclusion

HHV-7 was detected in the lungs of 6.24% of patients with severe pneumonia.

Study context

Population: Patients with severe pneumonia requiring invasive mechanical ventilation who underwent metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid, 12 centres, January 2019 to March 2023
Participants: 721 patients · 12 centres

Exposure: HHV-7 positive vs HHV-7 negative in lower respiratory tract
HHV-7 positiven = 45
Outcome: Incidence of HHV-7 detection in lower respiratory tract

Methodological detailsmulticentre, propensity-score matched

Multicentre
Propensity-score matched

Main finding

As reported in the abstract

HHV-7 detection in lower respiratory tract

HHV-7 positive

6.24%

45

Observational data: associations, not effects.

Further findings

Cytomegalovirus co-detection

P = 0.001

HHV-7 positive42.2%

HHV-7 negative20.7%

Epstein-Barr virus co-detection

P = 0.008

HHV-7 positive35.6%

HHV-7 negative18.2%

28-day mortality (propensity-matched) · propensity score matching

P = 0.395

HHV-7 positive46.2%

HHV-7 negative36.0%

Outcome	← Lower risk with HHV-7 positive ←→ Higher risk with HHV-7 positive →	HR (95% CI)	P value
28-day mortality (multivariate Cox regression) · adjusted for gender, age, SOFA score	0.20.5125	1.783 (0.936–3.400)	P = 0.079
	0.20.5125Hazard ratio (log scale)

Outcome	HHV-7 positive	HHV-7 negative	P value
Age	59.2	64.4	P = 0.032

28-day mortality (propensity-matched): matched for gender, age, SOFA at ICU admission, days from ICU admission to mNGS

Original publication

Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study. Crit Care. Published 23 June 2023. doi:10.1186/s13054-023-04530-6

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