Incidence and outcomes of AKI in postoperative patients admitted to ICU using full KDIGO criteria – a cohort study

Schiefer, J; Bernardi, MH; Lichtenegger, P; Schak, G; Atallah, L; Ristl, R; Ramazanova, D; Faybik, P

doi:10.1016/j.jclinane.2023.111156

Organ support & nutrition

Incidence and outcomes of acute kidney injury (AKI) in postoperative patients admitted to ICU using full KDIGO criteria – a cohort study

J Clin AnesthPublished 23 Jun 2023Retrospective cohort study

Read the original article ↗PubMed

Cite

Authors' conclusion

AKI based on full KDIGO criteria is very common in postoperative ICU patients and it is associated with stepwise increase in 28-days mortality.

Study context

Population: Adult postoperative ICU patients, tertiary university hospital, 2016–2018
Participants: 6,261 patients

Exposure: AKI stages 1–3
Outcome: All-cause mortality by AKI stage (complete KDIGO criteria)
Follow-up: 28 days

Methodological detailssingle-centre, tertiary university hospital, eight anaesthesiological/surgical ICUs

Single-centre
Tertiary university hospital
Eight anaesthesiological/surgical ICUs

Main finding

As reported in the abstract

28-day mortality by AKI stage (multivariate)

AKI 1°19.7%

AKI 2°28.4%

AKI 3°7.8%

Adjusted

Odds ratio (95% CI)P value

AKI 2°

2.81(1.55–5.24)

P < 0.001

AKI 3°

11.37(5.91–22.55)

P < 0.001

Overall 28-day mortality: 3% (n = 205)
AKI incidence: 3497 (55.9%)

Observational data: associations, not effects.

Further findings

Other predictors of 28-day mortality (multivariate)

	← Lower odds ←→ Higher odds →	OR (95% CI)	P value
Age	0.20.5125	1.02 (1.01–1.04)	P < 0.001
NYHA IV	0.20.5125	2.23 (1.03–4.43)	P = 0.042
Surgical reintervention within 48 h	0.20.5125	2.92 (1.76–4.72)	P = 0.001
Urgent surgery	0.20.5125	1.78 (1.15–2.71)	P = 0.01
Emergency surgery	0.20.5125	2.63 (1.58–4.31)	P = 0.001
	0.20.5125Odds ratio (log scale)

Outcome	← Lower odds vs cardiac surgery ←→ Higher odds vs cardiac surgery →	OR (95% CI)	P value
Other predictors of 28-day mortality (multivariate) · 28 daysVascular surgery vs Cardiac surgery	0.10.31310	2.01 (1.06–3.98)	P = 0.033
Other predictors of 28-day mortality (multivariate) · 28 daysOrthopedic and trauma surgery vs Cardiac surgery	0.10.31310	3.79 (1.98–7.09)	P < 0.001
	0.10.31310Odds ratio (log scale)

RRT

Patients receiving RRT: 235 (4%)

Original publication

Incidence and outcomes of AKI in postoperative patients admitted to ICU using full KDIGO criteria – a cohort study. J Clin Anesth. Published 23 June 2023. doi:10.1016/j.jclinane.2023.111156

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →