Incidence of bradycardia during noradrenaline or phenylephrine bolus treatment of postspinal hypotension in cesarean delivery: A randomized double‐blinded controlled trial
Authors' conclusion
When administered in intermittent bolus doses for the treatment of postspinal hypotension in elective cesarean delivery, noradrenaline, and phenylephrine have a similar incidence of bradycardia.
Study context
- Population
- Parturients undergoing elective cesarean delivery under spinal anesthesia
- Participants
- 76 participants
- Comparison
- Noradrenaline vs Phenylephrine
- Primary endpoint
- Bradycardia incidence (<60 bpm) with intermittent bolus administration
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
P = 0.16
Secondary outcomes
| Outcome | Noradrenaline | Phenylephrine | P value |
|---|---|---|---|
| Number of boluses required | 8 | 5 | P = 0.01 |
Other secondary outcomes (extreme bradycardia <40 bpm, number of bradycardia episodes, hypertension, hypotension)
- No significant intergroup difference
Safety
Neonatal umbilical vein or artery pH below 7.20
- No neonates had umbilical vein or artery pH below 7.20
Original publication
Incidence of bradycardia during noradrenaline or phenylephrine bolus treatment of postspinal hypotension in cesarean delivery: A randomized double‐blinded controlled trial. Acta Anaesthesiol Scand. Published 14 March 2023. doi:10.
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