Preventing Spinal Hypotension During Cesarean Birth With Two Initial Boluses of Norepinephrine in Chinese Parturients: A Randomized, Double-Blind, Controlled Trial
Primary resultResult — go to the resultOdds ratio 0.31 95% CI 0.14–0.71Authors' conclusion
With a fixed-rate norepinephrine infusion of 0.05 μg·kg -1 ·min -1 , the 0.10 μg/kg initial bolus was more effective in reducing the incidence of spinal hypotension compared with the 0.05 μg/kg initial bolus.
Study context
- Population
- Chinese parturients scheduled for cesarean birth under spinal anesthesia115 analysed
- Participants
- 120 participants
- Comparison
- 0.10 μg/kg vs 0.05 μg/kg
- Primary endpoint
- Frequency of spinal hypotension during cesarean birth
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Odds ratio
0.31
95% CI 0.14–0.71
P = 0.004
By group
0.10 μg/kg vs 0.05 μg/kg
OR 0.31 (95% CI 0.14–0.71); P = 0.004
Further findings
| Outcome | 0.05 μg/kg | 0.10 μg/kg | Difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Rescue doses of phenylephrine | — not stated in the abstract | 0 (bracketed spread (as printed) 0,0) | 0 (0–0) | P = 0.006 | |
| Duration of hypotension | 0 (bracketed spread (as printed) 0,2) | 0 (bracketed spread (as printed) 0,0) | 0 (0–0) | P = 0.006 | |
| 0000000Difference (linear scale) |
— not stated in the abstract
| Outcome | 0.05 μg/kg | 0.10 μg/kg | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Nausea or vomiting | 17.5% | 5.2% | 0.26 (0.07–0.99) | P = 0.04 | |
| 0.050.21520Odds ratio (log scale) |
Rescue doses of phenylephrine
- Fewer rescue doses of phenylephrine required in the 0.10 μg/kg group
Duration of hypotension
- Shorter duration of hypotension in the 0.10 μg/kg group
Safety
| Outcome | 0.05 μg/kg | 0.10 μg/kg | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Nausea or vomiting | 17.5% | 5.2% | 0.26 (0.07–0.99) | P = 0.04 | |
| 0.050.21520Odds ratio (log scale) |
Intraoperative hypertension, bradycardia, fetal outcomes
- Comparable between the 2 groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Preventing Spinal Hypotension During Cesarean Birth With Two Initial Boluses of Norepinephrine in Chinese Parturients: A Randomized, Double-Blind, Controlled Trial. Anesth Analg. Published 10 June 2022. doi:10.
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