Pediatric anesthesia & critical care
Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An updated systematic review and meta‐analysis
Pooled resultResult — go to the resultRelative risk 0.62 95% CI 0.46–0.83Authors' conclusion
The risk of emergence agitation in children after maintenance anesthesia with sevoflurane is significantly greater than with isoflurane; we did not find evidence of prolonged emergence or postanesthetic length of stay.
Study context
- Population
- Children <18 years of age
- Participants
- 523 children · 8 RCTs
- Comparison
- Isoflurane vs sevoflurane anesthesia
- Outcome
- Incidence of emergence agitation
Methodological detailsfixed or random effects model by heterogeneity, Cochrane Risk of Bias tool version 2
- Fixed or random effects model by heterogeneity
- Cochrane Risk of Bias tool version 2
Pooled result
As reported in the abstract
Relative risk
0.62
95% CI 0.46–0.83
P < 0.001
Isoflurane vs Sevoflurane
RR 0.62 (95% CI 0.46–0.83); P < 0.001
Further pooled results
| Outcome | RR (CI) | P value | |
|---|---|---|---|
| Emergence agitation, premedication (subgroup)I2 = 60.78% | 0.48 (0.28–0.82) | P = 0.01 | |
| Emergence agitation, intraoperative systemic analgesics (subgroup)I2 = 0.00% | 0.52 (0.37–0.75) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
Time to extubation, awakening time, PACU LOS
- Not significantly different
Original publication
Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An updated systematic review and meta‐analysis. Paediatr Anaesth. Published 13 December 2023. doi:10.
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