Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis
Authors' conclusion
Results showed that 16% and 20% lower of ECMO survival and overall survival in patients with NI than patients without NI, respectively.
Study context
- Population
- Adults supported by extracorporeal membrane oxygenation (ECMO)
- Participants
- 4,733 adults · 30 studies
- Comparison
- Infected vs non-infected patients on ECMO
- Outcome
- Incidence of NI
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Pooled incidence of NI (18 studies, 3424 patients)
Pooled incidence of NI
26%
95% CI 14–38%
ECMO-related nosocomial infections (NIs) per 1000 ECMO-days
1,249
Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| ECMO survivalLower ECMO survival in infected patients · random-effects model | RR for ECMO survival 0.84 (95% CI 0.74–0.96) | P = 0.01 | |
| Overall survivalLower overall survival in infected patients · random-effects model | RR for overall survival 0.80 (95% CI 0.71–0.90) | P < 0.001 | |
| 0.512Ratio (log scale) |
Most common NI sources
- Ventilator-associated pneumonia (VAP) and bloodstream infections (BSI) were the most common NI sources
ECMO-related NI rate
- ECMO-related NIs per 1000 ECMO-days, 30 studies, 4,733 patients
- 1,249
Original publication
Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis. Crit Care. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →