Inflammatory changes in the plasma and cerebrospinal fluid of patients with persistent pain and postpartum depression after elective Cesarean delivery: an exploratory prospective cohort study
Authors' conclusion
We observed differential levels of plasma and CSF inflammatory biomarkers in patients who developed persistent pain and PPD compared with those who did not.
Study context
- Population
- Term patients with singleton pregnancies undergoing elective Cesarean delivery under neuraxial anesthesia63 completed
- Participants
- 80 patients
- Exposure
- Patients who developed persistent pain and/or PPD vs those who did not
- Primary outcomen = 23
- Outcome
- Persistent pain and/or postpartum depression (PPD); primary aim: inflammatory marker levels between groups
- Follow-up
- Three months
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Inflammatory marker levels
Incidence of persistent pain and/or PPD at three months
23
37%
Observational data: associations, not effects.
Further findings
Preoperative plasma TGF-β1 concentration · two-sided Mann-Whitney test
P = 0.04
CSF IL-1β concentration · two-sided Mann-Whitney test
P = 0.03
Original publication
Inflammatory changes in the plasma and cerebrospinal fluid of patients with persistent pain and postpartum depression after elective Cesarean delivery: an exploratory prospective cohort study. Can J Anaesth. Published 6 November 2023. doi:10.
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