Cerebrospinal fluid proteome of patients with persistent pain and/or postpartum depression after elective cesarean delivery: An exploratory prospective cohort study
Authors' conclusion
These results suggest that the CSF complement and coagulation cascades may play a role in patients who develop postpartum pain or PPD 3 months later.
Study context
- Population
- Patients undergoing elective cesarean delivery (CD) under neuraxial anaesthesia61 analysed
- Participants
- Eighty patients
- Exposure
- Persistent pain and/or PPD vs neither disorder at 3 months post-CD
- Persistent pain and/or PPDn = 21
- Outcome
- Preoperative CSF proteome changes associated with persistent pain or PPD
- Follow-up
- 3 months post-CD
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Preoperative CSF proteome
- Proteins quantified in each CSF sample
- Over 1600
- Proteins nominally differentially expressed, persistent pain and/or PPD vs neither
- Forty-three
Observational data: associations, not effects.
Original publication
Cerebrospinal fluid proteome of patients with persistent pain and/or postpartum depression after elective cesarean delivery: An exploratory prospective cohort study. J Clin Anesth. Published 5 May 2025. doi:10.
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