Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis
Pooled resultResult — go to the resultRelative risk 0.59 95% CI 0.47–0.74Authors' conclusion
Our comprehensive and up-to-date review demonstrates that adjunct TPE may provide potential survival benefits when compared to standard care for critically ill adult patients with sepsis-induced organ dysfunction.
Study context
- Population
- Critically ill adults with sepsis-induced organ dysfunction
- Participants
- 937 adults · 5 randomized clinical trials (RCTs) · 15 MCSs
- Comparison
- Adjunct therapeutic plasma exchange (TPE) vs standard therapy alone
- TPEn = 300
- Standard therapyn = 327reference
- Outcome
- Short-term mortality
Methodological detailsrandom effects model
- Random effects model
Pooled result
As reported in the abstract
Relative risk
0.59
95% CI 0.47–0.74
TPE vs Standard therapy
RR 0.59 (95% CI 0.47–0.74)
Further pooled results
Clinical and/or laboratory recovery (systematic review, all 20 trials)
- Faster clinical and/or laboratory recovery with adjunct TPE
Original publication
Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis. Crit Care. Published 4 January 2024. doi:10.
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