Inhaled drug delivery: a randomized study in intubated patients with healthy lungs
Authors' conclusion
Optimizing the administration technique enables a significant increase in inhaled drug delivery to the lungs, including peripheral airways.
Study context
- Population
- Intubated postoperative neurosurgery patients with healthy lungs
- Participants
- 31 patients
- Comparison
- Four aerosol delivery configurations during invasive ventilation
- Primary endpoint
- Lung deposition of a radiolabeled aerosol (% of nominal dose, planar scintigraphy)
Methodological detailsin vivo and in vitro
- In vivo and in vitro
Primary result
As reported in the abstract
Lung delivery (% of nominal dose)
Specific circuit for aerosol therapy (SCAT)
19.7%
range 14.0–24.5
P < 0.01
Further findings
Regional lung distribution
- Around 50 to 60% of lung doses reached the outer region of both lungs in all groups
- Inner and outer lung region doses significantly increased in SCAT (p < 0.01), except outer right lung region in the conventional group (drug trickling to the right bronchi)
Heated humidifier off vs on
- Similar lung delivery whether the heated humidifier was switched off or left on
In vitro inhaled dose vs lung dose correlation
- Correlation R
- 0.768
- p < 0.001
Original publication
Inhaled drug delivery: a randomized study in intubated patients with healthy lungs. Ann Intensive Care. Published 11 December 2023. doi:10.
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