Cardiac arrest & resuscitation
Innate Immune Response After Cardiac Arrest (INNATUS): A Study Protocol for an Observational Single‐Center Pilot Study
Study context
- Population
- Adult cardiac arrest (CA) patients admitted to the ICU after successful resuscitation
- Participants
- 40 vs 40
- Planned comparison
- CA patients vs elective coronary artery bypass graft (CABG) controls
- CAn = 40
- CABGn = 40reference
- Primary endpoint
- Severity of organ failure (modified SOFA score) during the first 96 h after ROSC and neurological outcome (Modified Rankin Scale) at 6 months
Methodological detailsEnrollment January 2022 to April 2025; last follow-up due October 2025, Blood samples at ICU admission, 4, 8, 12 and 24 h after return of spontaneous circulation (ROSC) and mornings of Days 1-4; proteomic, transcriptomic and flow cytometric analyses
- Enrollment January 2022 to April 2025; last follow-up due October 2025
- Blood samples at ICU admission, 4, 8, 12 and 24 h after ROSC and mornings of Days 1-4; proteomic, transcriptomic and flow cytometric analyses
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Innate Immune Response After Cardiac Arrest (INNATUS): A Study Protocol for an Observational Single‐Center Pilot Study. Acta Anaesthesiol Scand. Published 8 July 2025. doi:10.
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