Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy
Authors' conclusion
This comprehensive review highlights the potential of biomarkers to transform acute and chronic pain management, offering hope for improved diagnosis, treatment personalization, and patient outcomes.
Study context
- Population
- Patients with acute and chronic pain
- Outcome
- Acute and chronic pain biomarkers
Main finding
As reported in the abstract
- Neuroimaging (MRI, positron emission tomography) provides insights into structural and functional abnormalities related to pain
- Electrophysiological methods (EEG, magnetoencephalography) assess dysfunctional processing in the pain neuroaxis
- Molecular biomarkers (cytokines, proteomics, metabolites) offer diagnostic and prognostic potential, though extensive validation is needed
- Emergence of composite, multimodal strategies integrating psychosocial factors to improve precision and applicability of biomarkers in chronic pain management
Original publication
Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy. Reg Anesth Pain Med. Published 5 February 2025. doi:10.
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