Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study
Main findingResult — go to the resultOdds ratio 1.05 95% CI 0.60–1.83Authors' conclusion
In women who receive epidural analgesia during labour, genetically predicted (higher) interleukin-1 receptor antagonist levels do not alter the incidence of maternal intrapartum fever or use of intrapartum antibiotics.
Study context
- Population
- Women ≥18 yr receiving epidural analgesia during labour, excluding pre-existing fever, antibiotic therapy or immunodeficiencygenotyped
- Participants
- 624 women
- Exposure
- IL-1Ra allele score 0 vs ≥1
- Allele score 0n = 74reference
- Allele score ≥1n = 550
- Outcome
- Composite of:
- Maternal intrapartum fever (>38°C)
- Intrapartum antibiotics after epidural placement
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Main finding
As reported in the abstract
Odds ratio
1.05
95% CI 0.60–1.83
P = 0.89
Events by group
Allele score 0 vs Allele score ≥1
OR 1.05 (95% CI 0.60–1.83); P = 0.89
Observational data: associations, not effects.
Further findings
Fever or antibiotics, all genotyped women
- Developed maternal fever or received antibiotics
- 155 (24.8%)
Original publication
Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study. Br J Anaesth. Published 14 May 2025. doi:10.
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