Pediatric anesthesia & critical care
Intraoperative Bronchospasm and Future Asthma in Children: A Retrospective Matched Cohort Study
Main finding · Future asthma diagnosisResult — go to the resultOdds ratio 2.29 95% CI 1.10–4.74Authors' conclusion
This study shows intraoperative bronchospasm is associated with an increased risk of future asthma in children.
Study context
- Population
- Children aged 2–18 years undergoing non-cardiac surgery under GA, 2014–2020
- Participants
- 44,284 children
- Exposure
- Intraoperative bronchospasm vs no bronchospasm
- Bronchospasmn = 128
- Outcome
- Subsequent asthma diagnosis
Methodological detailsmatched cohort
- Matched cohort
Main finding
Future asthma diagnosis
Odds ratio
2.29
95% CI 1.10–4.74
P = 0.03
Bronchospasm vs No bronchospasm
OR 2.29 (95% CI 1.10–4.74); P = 0.03
As reported in the abstract
- Asthma diagnosed overall
- 1238 (2.8%)
- Asthma cases with intraoperative bronchospasm
- 8 of 1238, 0.7%
Observational data: associations, not effects.
Further findings
Other factors associated with future asthma (adjusted)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Male sexAfter adjustment for confounders | 1.57 (1.39–1.76) | P < 0.001 | |
| Younger ageAfter adjustment for confounders | 0.96 (0.94–0.97) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Mean PIP and asthma (subgroup with positive pressure ventilation)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Mean PIP | 1.50 (1.30–1.74) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
- Mean PIP and asthma (subgroup with positive pressure ventilation): subgroup n = 35 770
Original publication
Intraoperative Bronchospasm and Future Asthma in Children: A Retrospective Matched Cohort Study. Paediatr Anaesth. Published 4 August 2025. doi:10.
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