Intraoperative dexamethasone and chronic postsurgical pain: a propensity score-matched analysis of a large trial
Primary result · CPSP after propensity score matchingResult — go to the resultAdjusted relative risk 0.88 95% CI 0.61–1.27Authors' conclusion
Dexamethasone does not increase the risk of chronic postsurgical pain after major noncardiac surgery.
Study context
- Population
- Patients undergoing major noncardiac surgery (ENIGMA-II trial chronic postsurgical pain (CPSP) dataset)analysed
- Participants
- 2,999 patients
- Comparison
- Intraoperative dexamethasone vs no dexamethasone
- Dexamethasonen = 973
- No dexamethasonen = 2,026reference
- Primary endpoint
- Incidence of chronic postsurgical pain (CPSP)
- Follow-up
- 12 months
Methodological detailspropensity score-matched, inverse probability weighting
- Propensity score-matched
- Inverse probability weighting
Primary result
CPSP after propensity score matching
Adjusted relative risk
0.88
95% CI 0.61–1.27
P = 0.493
Events by treatment group
Dexamethasone vs No dexamethasone
adjusted RR 0.88 (95% CI 0.61–1.27); P = 0.493
As reported in the abstract
Further findings
CPSP, unadjusted · 12 months
unadjusted OR 0.76 (0.78–1.00) · P = 0.052
| Outcome | P value |
|---|---|
| 'Least pain' and 'pain right now'Higher in the dexamethasone group | P = 0.033 |
| 'Least pain' and 'pain right now'Higher in the dexamethasone group | P = 0.034 |
Quality of life and pain interference with daily activities
- No difference between groups
Original publication
Intraoperative dexamethasone and chronic postsurgical pain: a propensity score-matched analysis of a large trial. Br J Anaesth. Published 24 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →