Perioperative medicine & outcomes
Brain-derived tau in plasma and cerebrospinal fluid after surgery: a prospective cohort substudy
Authors' conclusion
Early postoperative increases in plasma t-tau are consistent with a CNS origin but not concomitant neuronal injury. Instead, the early plasma BD-tau increase and the inverse association between CSF and plasma BD-tau could indicate a redistribution of tau from the CNS to plasma.
Study context
- Population
- Adult patients undergoing hip and knee arthroplasty
Primary result
As reported in the abstract
Peak increase
254%
137–382%, P<0.001
Further findings
| Outcome | β | P value |
|---|---|---|
| Association of plasma BD-tau with plasma t-tauPlasma BD-tau vs plasma t-tau | 1.09 (95% CI 0.95–1.23) | P < 0.001 |
| Association of plasma BD-tau with CSF BD-tauPlasma BD-tau vs CSF BD-tau · inversely associated | −0.71 (CI −0.97 to −0.45) | P < 0.001 |
Plasma brain-derived tau (BD-tau), median (IQR) percentage change from baseline · 48 h
- Remained elevated
- 31% (6-75%, P<0.001)
CSF BD-tau, median (IQR) percentage change from baseline · 4 h
- Unchanged
CSF BD-tau, median (IQR) percentage change from baseline · 48 h
- Increase
- 51% (21-82%, P=0.004)
Postoperative plasma BD-tau, CSF albumin and cognitive performance · 3 months
- Higher postoperative plasma BD-tau associated with both higher CSF albumin and worse cognitive performance at 3 months
Original publication
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