Perioperative medicine & outcomes
Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium
Authors' conclusion
Preoperative plasma concentrations of Tau-PT217 and Tau-PT181 were associated with postoperative delirium, with Tau-PT217 being a stronger indicator of postoperative delirium than Tau-PT181.
Study context
- Population
- Patients 65 years old or older undergoing knee replacement, hip replacement, or laminectomyof 491 screened
- Participants
- 139 patients
- Exposure
- Preoperative plasma Tau-PT217 and Tau-PT181 concentrations and postoperative delirium
- Outcome
- Postoperative delirium
Methodological detailsbiomarker association study
- Biomarker association study
Main finding
As reported in the abstract
Tau-PT217
0.969
AUC
Tau-PT181
0.885
AUC
Odds ratio per unit change (95% CI)P value
Tau-PT217
2.05(1.61–2.62)
P < 0.001- Tau-PT181
- OR per unit change 4.12 (95% CI 2.55--6.67); P < 0.001
Observational data: associations, not effects.
Further findings
Delirium severity
| β per unit change (95% CI) | P value | |
|---|---|---|
| Tau-PT217 | 0.14 (0.09–0.19) | P < 0.001 |
| Tau-PT181 | 0.41 (0.12–0.70) | P = 0.006 |
Original publication
Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium. Ann Surg. Published 6 July 2022. doi:10.
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