Perioperative medicine & outcomes
Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan
Authors' conclusion
SOMAscan can characterize both short- and long-term surgery-induced protein alterations in plasma and CSF. Acute plasma protein changes at POD1 parallel changes in PO1MO CSF and suggest 15 potential biomarkers for longer-term neuroinflammation that warrant further investigation.
Study context
- Population
- Older patients undergoing elective hip and knee replacement surgery with spinal anaesthesia (RISE study)plasma n = 14
- Exposure
- POD1 and PO1MO vs PREOP protein levels in plasma and cerebrospinal fluid (CSF)
- Outcome
- Surgery-associated differentially expressed proteins in plasma and CSF (P < .05; |FC| > 1.2)
Methodological detailsproteomic analysis, secondary analysis of the RISE study, SOMAscan assay (1305 proteins), systems biology pathway analysis
- Proteomic analysis
- Secondary analysis of the RISE study
- SOMAscan assay (1305 proteins)
- Systems biology pathway analysis
Main finding
As reported in the abstract
Proteins with altered levels vs PREOP
- Plasma proteins changed at POD1 vs PREOP
- 343
- Plasma proteins altered at PO1MO vs PREOP
- 67
- CSF proteins altered at PO1MO vs PREOP
- 79
- Plasma proteins similarly changed at POD1 and PO1MO, primarily immune response and inflammation
- 21
- Proteins shared by plasma and CSF at PO1MO
- 8
- Proteins shared by POD1 plasma and PO1MO CSF, mostly regulated by IL-6 or TGFB1, linked to inflammatory response
- 15
Observational data: associations, not effects.
Original publication
Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan. Anesth Analg. Published 7 April 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →