Intraoperative dexamethasone is associated with a lower risk of respiratory failure in thoracic surgery: Observational cohort study (SURTHODEX)
Main finding · Respiratory complicationsResult — go to the resultAdjusted relative risk 0.65 95% CI 0.43–0.97Authors' conclusion
Dexamethasone administration was associated with a reduction in postoperative respiratory complications.
Study context
- Population
- Adults undergoing elective thoracic surgery, 2012 to 2020
- Participants
- 1,247 adults
- Exposure
- Intraoperative dexamethasone vs no dexamethasone
- Dexamethasone (DXM)n = 897
- Controlsn = 350reference
- Outcome
- Onset of acute respiratory failure
- Follow-up
- Within 7 days post-surgery
Methodological detailssingle-centre, overlap propensity score analysis
- Single-centre
- Overlap propensity score analysis
Main finding
Respiratory complications
Adjusted relative risk
0.65
95% CI 0.43–0.97
DXM vs Controls
adjusted RR 0.65 (95% CI 0.43–0.97)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Composite infectious criteria
- Significant decline in composite infectious criteria, adjusted RR
- 0.76 (95% CI 0.63-0.93)
- Overlap propensity score analysis
Cardiac complications (composite criterion)
- Significant reduction in cardiac complications, adjusted RR
- 0.68 (95% CI 0.51-0.9)
- Overlap propensity score analysis
Mechanical complications
- No association with mechanical complications
Mortality · 30 days
- No association with 30-day mortality, adjusted RR
- 0.43 (95% CI 0.17-1.09)
- Overlap propensity score analysis
Hospital LOS
- No association with length of hospital stay, adjusted RR
- 0.85 (95% CI 0.71-1.02)
- Overlap propensity score analysis
Original publication
Intraoperative dexamethasone is associated with a lower risk of respiratory failure in thoracic surgery: Observational cohort study (SURTHODEX). Anaesth Crit Care Pain Med. Published 6 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →