Pediatric anesthesia & critical care
Intraoperative dexmedetomidine and acute kidney injury in paediatric noncardiac surgery: a retrospective propensity score-matched analysis
Main finding · AKI within 7 days after surgeryResult — go to the resultOdds ratio 0.43 95% CI 0.27–0.66Authors' conclusion
This retrospective analysis of a single-centre paediatric noncardiac surgery cohort suggests that intraoperative dexmedetomidine infusion was associated with a lower incidence of AKI within 7 days after surgery.
Study context
- Population
- Paediatric patients undergoing noncardiac surgery, January 2019–July 20211,858/4091 received dexmedetomidine after matching
- Exposure
- Dexmedetomidine vs No dexmedetomidine
- Outcome
- Acute kidney injury (AKI)
- Follow-up
- Within 7 days after surgery
Methodological detailspropensity-score matched, single-centre, multivariable logistic and linear regression in matched cohort
- Propensity-score matched
- Single-centre
- Multivariable logistic and linear regression in matched cohort
Main finding
AKI within 7 days after surgery
Odds ratio
0.43
95% CI 0.27–0.66
P < 0.001
By group
Dexmedetomidine vs No dexmedetomidine
OR 0.43 (95% CI 0.27–0.66); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Postoperative ICU admission | 0.35 (0.30–0.42) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Length of hospitalisation · shorter hospitalisation
P < 0.001
In-hospital mortality
- Similar between the matched groups
Safety
Intraoperative bradycardia and hypotension
- Similar between the matched groups
Original publication
Intraoperative dexmedetomidine and acute kidney injury in paediatric noncardiac surgery: a retrospective propensity score-matched analysis. Br J Anaesth. Published 12 December 2024. doi:10.
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