Perioperative medicine & outcomes
Intraoperative electroencephalogram-derived measures and their association with postoperative delirium: a systematic review and meta-analysis
Authors' conclusion
Alpha oscillation and burst suppression measures appear to be robust indicators of POD vulnerability, even in the presence of pEEG-guided anaesthesia. The use of pEEG-guided anaesthesia did not eliminate the associations between these measures and POD.
Study context
- Population
- Older surgical patients with intraoperative EEG
- Participants
- 13,115 patients · 42 studies
- Comparison
- Non-proprietary intraoperative EEG-derived measures and their association with postoperative delirium (POD)
- Outcome
- POD
Methodological detailsPRISMA, prospectively registered protocol, 49 EEG-derived measures identified; meta-analysis for measures reported in ≥3 studies; risk of bias by Quality in Prognostic Studies tool
- PRISMA
- Prospectively registered protocol
- 49 EEG-derived measures identified; meta-analysis for measures reported in ≥3 studies; risk of bias by Quality in Prognostic Studies tool
Pooled result
As reported in the abstract
Association of intraoperative EEG-derived measures with POD
- Lower intraoperative alpha and delta mean power significantly associated with POD
- Lower alpha peak frequency significantly associated with POD
- Lower spectral edge frequency significantly associated with POD
- Presence and duration of burst suppression associated with POD
Further pooled results
POD incidence
- Mean incidence of POD
- 18.8%
Delta mean power, non-pEEG-guided studies (secondary analysis)
- Delta mean power not significantly associated with POD
Original publication
Intraoperative electroencephalogram-derived measures and their association with postoperative delirium: a systematic review and meta-analysis. Br J Anaesth. Published 26 September 2025. doi:10.
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