Pain medicine

Intraoperative fentanyl in endoscopic procedures and their impact on postanesthesia care unit (PACU) time and costs

Perioper Med (Lond)Published Retrospective cohort study

Authors' conclusion

Intraoperative fentanyl increases PACU duration by approximately 4 min per patient in endoscopies, without markedly improving pain management.

Study context

Population
Outpatients undergoing upper/lower endoscopy, 2020–2022
Participants
11,488 outpatients
Exposure
Intraoperative fentanyl vs no fentanyl
  • Fentanyln = 5,787
Outcome
PACU duration
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Median PACU time

P < 0.01

Observational data: associations, not effects.

Further findings

Postoperative pain score > 5

No pain post-surgery

OutcomeP value
Fentanyl receipt in long PACU stay (> 50 min) vs shorter stayP < 0.01
NRS pain > 5, long vs shorter PACU stayP < 0.01
Fentanyl receipt in long PACU stay (> 50 min) vs shorter stay — Long PACU stay (> 50 min)
5225 (45.5%)
  • Fentanyl receipt in long PACU stay (> 50 min) vs shorter stay: Long stay 56.3%
  • Fentanyl receipt in long PACU stay (> 50 min) vs shorter stay: Shorter stay 45.4%
  • Numeric Rating Scale (NRS) pain > 5, long vs shorter PACU stay: Long stay 3.6%
  • NRS pain > 5, long vs shorter PACU stay: Shorter stay 1.2%

Postoperative pain score > 5

Fentanyl did not significantly reduce postoperative pain

No pain post-surgery

Fentanyl recipients did not have shorter PACU stays within any pain scale category

Costs (financial simulation)

Annual saving with fentanyl-free anaesthesia, at least
US $100,308

Original publication

Intraoperative fentanyl in endoscopic procedures and their impact on PACU time and costs. Perioper Med (Lond). Published 20 March 2025. doi:10.1186/s13741-025-00515-x

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