Perioperative medicine & outcomes
Intraoperative Hemodynamic Management during Liver Transplantation and Postoperative Morbidity: A Multicenter Cohort Study
Authors' conclusion
A higher fluid balance and higher doses of vasopressors were not associated with a higher risk of 7-day early allograft dysfunction or primary graft nonfunction after liver transplantation.
Study context
- Population
- Consecutive liver transplant recipients at eight centres in Canada and France, January 2021–May 2023836 with complete data
- Participants
- 852 recipients
- Exposure
- Intraoperative fluid balance and vasopressor doses
- Outcome
- Early allograft dysfunction or primary graft nonfunction
- Follow-up
- 7 days
Methodological detailsconsecutive recipients, regression models adjusted for confounders including intraoperative hypotension
- Consecutive recipients
- Regression models adjusted for confounders including intraoperative hypotension
Main finding
As reported in the abstract
7-day early allograft dysfunction or primary graft nonfunction
Adjusted relative risk (95% CI)
Fluid balance, per liter
1.02(0.97–1.06)
Vasopressor dose, per 25 μg/kg norepinephrine equivalent
1.03(0.99–1.06)
Each row per its own increment, as printed
- Incidence of 7-day early allograft dysfunction or primary graft nonfunction (236 patients)
- 28%
Observational data: associations, not effects.
Original publication
Intraoperative Hemodynamic Management during Liver Transplantation and Postoperative Morbidity: A Multicenter Cohort Study. Anesthesiology. Published 30 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →