Cardiothoracic & vascular anesthesia
Postoperative Liver Dysfunction After Lung Transplantation With Extracorporeal Life Support and 1-Year Mortality—A Cohort Study
Authors' conclusion
Lung transplantation involving CPB or extended perioperative ECMO support significantly increases the risk of severe postoperative liver dysfunction associated with poorer outcomes. However, brief intraoperative ECMO deployment does not appear to carry this risk.
Study context
- Population
- Consecutive lung transplant patients, single university hospital, January 2009–April 2023
- Participants
- 1,350 consecutive patients
- Exposure
- Hypoxic liver dysfunction vs Drug-induced liver injury vs Cholestasis
- Outcome
- Incidence of hepatic injury within the first 12 postoperative days, by type
- Follow-up
- First 12 postoperative days
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Hypoxic liver dysfunction
4%
Drug-induced liver injury
23%
Cholestasis
52%
Observational data: associations, not effects.
Further findings
Intensive care unit (ICU) LOS
- All types of liver injury associated with increased ICU LOS
1-year mortality
- Only hypoxic liver dysfunction (vs drug-induced injury) independently linked with increased 1-year mortality
- 35%
- Distinction between drug-induced liver injury and mild hypoxic liver dysfunction difficult
Perioperative support in hypoxic liver dysfunction
- More frequently operated on cardiopulmonary bypass (CPB) or required prolonged extracorporeal membrane oxygenation (ECMO) support
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative Liver Dysfunction After Lung Transplantation With Extracorporeal Life Support and 1-Year Mortality—A Cohort Study. J Cardiothorac Vasc Anesth. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →