Cardiothoracic & vascular anesthesia
Postcardiotomy Acute Liver Injury: A Retrospective Cohort
Authors' conclusion
The incidence and prognostic value of postoperative liver injury strongly depend on the diagnostic definition adopted. HH and SIELI identify a small subset of patients with markedly increased morbidity, whereas ALF, as currently defined, appears to lack prognostic relevance in this surgical setting.
Study context
- Population
- Consecutive adults undergoing cardiac surgery with cardiopulmonary bypass (CPB), tertiary cardiac surgery center
- Participants
- 2,038 consecutive patients
- Exposure
- Severe ischemic liver injury (SIELI) vs hypoxic hepatitis (HH) vs acute liver failure (ALF)
- SIELIn = 19
- HHn = 26
- ALFn = 544
- Outcome
- Incidence of acute liver injury by definition
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Postoperative complications and outcomes
- HH or SIELI: significantly higher rates of reoperation and bleeding complications and more RBC, FFP and platelet transfusions vs patients without liver injury
- ALF not associated with adverse prognostic implications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postcardiotomy Acute Liver Injury: A Retrospective Cohort. J Cardiothorac Vasc Anesth. Published 15 May 2026. doi:10.
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