Cardiothoracic & vascular anesthesia
Effect of a Combined Drug Approach on the Severity of Ischemia-Reperfusion Injury During Liver Transplant: A Randomized Clinical Trial
Primary resultResult — go to the resultGeometric mean ratio 0.87 95% CI 0.58–1.31Authors' conclusion
In this randomized clinical trial, the combined drug approach targeting the post-cold storage graft and the recipient did not decrease ischemic-reperfusion injury.
Study context
- Population
- Adults wait-listed for a first solitary full-size liver transplant, Belgium, 2013–201872 per protocol
- Participants
- 93 participants
- Comparison
- Combined drug approach with standard of care vs standard of care only
- Combined drug approachn = 36
- Controln = 36reference
- Primary endpoint
- Posttransplant peak serum AST level
- Follow-up
- Within the first 72 hours
Methodological detailsunicentric, investigator-driven, open-label, 2 parallel arms
- Unicentric
- Investigator-driven
- Open-label
- 2 parallel arms
Primary result
As reported in the abstract
Geometric mean ratio
0.87
95% CI 0.58–1.31
P = 0.49
By group
Combined drug approach vs Control
geometric mean ratio 0.87 (95% CI 0.58–1.31); P = 0.49
Secondary outcomes
Postreperfusion syndrome, ischaemia-reperfusion injury score, early allograft dysfunction, surgical complications, ischaemic cholangiopathy, AKI, acute cellular rejection, graft and patient survival
- No significant differences between the groups
Original publication
Effect of a Combined Drug Approach on the Severity of Ischemia-Reperfusion Injury During Liver Transplant: A Randomized Clinical Trial. JAMA Netw Open. Published 1 February 2023. doi:10.
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