Cardiothoracic & vascular anesthesia
Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units
Authors' conclusion
In this retrospective analysis of national donor and transplant recipient data, although lung donation rates were higher from deceased organ donors after brain death cared for in independent DCUs, lungs recovered from donors in hospital-based DCUs survived longer.
Study context
- Population
- Deceased organ donors (aged ≥16 years) after brain death with organ recovery April 2017–June 2022, and recipients of lung transplants from those donors1,657 transplant recipients
- Participants
- 5,149 donors
- Exposure
- Organ recovery in independent vs hospital-based donor care units
- Independent DCUn = 3,683
- Hospital-based DCUn = 1,466reference
- Outcome
- Duration of transplanted lung (graft) survival among recipients of lungs from cohort donors
- Follow-up
- Through December 31, 2023
Methodological detailsnational registry (OPTN), 21 US donor service areas
- National registry (OPTN)
- 21 US donor service areas
Main finding
Transplanted lung (graft) survival
HR for graft failure
1.85
95% CI 1.28–2.65
By group
Independent DCU vs Hospital-based DCU
HR for graft failure 1.85 (95% CI 1.28–2.65)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Unadjusted lung donation rate
P < 0.001
Unadjusted lung donation rate
- Unadjusted lung donation rates higher in donor care units (DCUs) than local hospitals
Original publication
Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units. JAMA Netw Open. Published 3 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →