Cardiothoracic & vascular anesthesia
Lower tidal volume ventilation post‐bilateral lung transplantation is associated with ventilator‐free days
Authors' conclusion
Lower tidal volume ventilation indexed to donor predicted body weight is associated with more ventilator-free days post-bilateral lung transplantation.
Study context
- Population
- Consecutive adult bilateral lung transplant recipients, 2015–2021, ventilated ≥24 h post-surgery
- Participants
- 111 recipients
- Exposure
- Lower vs higher tidal volume indexed to donor predicted body weight
- Outcome
- Ventilator-free days
- Follow-up
- First 28 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Ventilator-free days (tidal volume indexed to donor predicted body weight)
Median ventilator-free days, entire cohort
25
21–26
Observational data: associations, not effects.
Further findings
| Outcome | SHR for successful extubation (CI) | P value | |
|---|---|---|---|
| Cumulative incidence of successful extubationLower tidal volume vs Higher tidal volume · competing risks regression | 1.54 (1.07–2.20) | P = 0.02 | |
| Cumulative incidence of successful extubationLower tidal volume vs Higher tidal volume · competing risks regression | 1.87 (1.07–3.27) | P = 0.03 | |
| 0.20.5125SHR for successful extubation (log scale) |
- Cumulative incidence of successful extubation: tidal volume indexed to donor predicted body weight after 48 h
- Cumulative incidence of successful extubation: tidal volume indexed to donor predicted body weight after 72 h
90-day survival
- VFDs and lower tidal volume associated with increased 90-day survival
- Cox proportional hazards model
Original publication
Lower tidal volume ventilation post‐bilateral lung transplantation is associated with ventilator‐free days. Acta Anaesthesiol Scand. Published 27 March 2025. doi:10.
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