Cardiothoracic & vascular anesthesia
Driving Pressure–Guided Tidal Volume Titration Reduces Lung Injury in Thoracic Surgery With One-Lung Ventilation: A Randomized Clinical Trial
Primary result · IL-6 concentration in the dependent lung after OLVResult — go to the resultMean difference −0.46 cm H2O CI −0.86 to −0.05Authors' conclusion
Driving pressure-guided tidal volume titration significantly reduces IL-6 levels in bronchoalveolar lavage fluid from the dependent lung following OLV in patients undergoing thoracic surgery, compared to conventional ventilation using 8 mL/kg PBW.
Study context
- Population
- Patients undergoing thoracic surgery with one-lung ventilation (OLV), single-centre academic hospital in China
- Participants
- 96 patients
- Comparison
- Driving pressure-guided tidal volume vs 8 mL/kg predicted body weight (PBW) during OLV
- Driving pressure-guidedn = 46
- Controln = 50reference
- Primary endpoint
- IL-6 concentration in the dependent lung (bronchoalveolar lavage fluid) following OLV
- Follow-up
- Following OLV
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
IL-6 concentration in the dependent lung after OLV
Mean difference
−0.46 cm H2O
CI −0.86 to −0.05
P = 0.025
By group
Driving pressure-guided
5.31
bracketed value as printed 3.62
Control
7.37
bracketed value as printed 5.21
Driving pressure-guided vs Control
mean difference −0.46 cm H2O (CI −0.86 to −0.05); P = 0.025
Further findings
- Tidal volume in the driving pressure-guided group during OLV · 15 and 45 minutes of OLV
- 4.65 · bracketed range as printed 4.23–5.65 · mL/kg
- Tidal volume in the driving pressure-guided group during OLV: 4.65 at 15 minutes
PPCs and oxygenation index 45 minutes after start of OLV
- No significant differences between groups
Original publication
Driving Pressure–Guided Tidal Volume Titration Reduces Lung Injury in Thoracic Surgery With One-Lung Ventilation: A Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 19 November 2025. doi:10.
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